NEXT GENERATION HUMANIZED MICE
Our laboratory uses patients-derived xenografts (PDX) to assess human hematopoietic stem and progenitor cell function and for the preclinical testing of candidate compounds (Theocharides et al., Haematologica 2016, Lysenko et al., Blood advances 2020). We use MISTRG mice which have been genetically engineered to express and produce human cytokines, which supports the development of human myeloid cells
(Rongvaux et al., Nature Biotechnol. 2014).