Petri Dish

CALRETICULIN MUTATIONS

Our group has previously shown that patients with myeloproliferative neoplasms (MPN) and homozygous CALR mutations develop a maturation defect in Myeloperoxidase (MPO), a GP normally folded by CALR (Theocharides et al., Blood 2016). Based on these findings, we hypothesize that CALR mutations affect GP maturation and potentially may lead to mutant-specific protein-protein interactions in signaling pathways that further contribute to the pathogenesis of MPN.