Closeup of a Petri Dish

PATIENT-DERIVED XENOGRAFTS

Our laboratory has a long-standing experience in the development and applications of patient-derived xenograft (PDX) models for hematological malignancies. We have recently described a novel model for patients with myelofibrosis using next generation humanized MISTRG mice (Lysenko et al., Blood advances 2020). MISTRG mice have been genetically engineered to express and produce human cytokines, which supports the development of human myeloid cells. These models are particularly useful in the functional assessment of human hematopoietic stem and progenitor cells and the preclinical testing of candidate compounds.